Simplified Simultaneous Assay of Total Plasma Homocysteine and Methionine by HPLC and Pulsed Integrated Amperometry
نویسندگان
چکیده
منابع مشابه
Simplified simultaneous assay of total plasma homocysteine and methionine by HPLC and pulsed integrated amperometry.
known naturally occurring degradation product may be of interest with respect to the etiology of neural tube defects or the homocysteinemia that is associated with this variant. At a more practical level, the comparative evaluation of the two assays reported here indicates that folate concentrations are not being measured accurately by one of the assays in the 5% to 15% of people who are homozy...
متن کاملMeasurement of Plasma Total Homocysteine by HPLC
23 mg/L for the evaluation tube, with an average difference between tube types of 35 6 4.3 mg/L. The test results for blood lead and EP on samples collected in the evaluation tubes were clearly equivalent to those collected in the independently certified, lead-free control tubes. The availability of pediatric pretested lead-free collection tubes will contribute to accurate and reliable diagnosi...
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Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolite. The metabolite was isolated, and its structure was identified by quadrupole time-of-flight-mas...
متن کاملPreparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma
Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolite. The metabolite was isolated, and its structure was identified by quadrupole time-of-flight-mas...
متن کاملStandardization (external and internal) of HPLC assay for plasma homocysteine.
Measurement of plasma homocysteine may be of value in several clinical conditions including homocystinuria, ath-erosclerosis, thrombophilia, and folate/vitamin B 12 deficiency. The increasing interest in measuring total homo-cysteine in plasma has led to the development of several different methods [1]. A widely used technique for measuring total plasma homocysteine is reversed-phase HPLC with ...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 1998
ISSN: 0009-9147,1530-8561
DOI: 10.1093/clinchem/44.1.188